#!/usr/bin/env perl use strict; use warnings; use autodie; my $in_file_name_id = 'pm_1055846_name_id_data.txt'; my $in_file_name_replace = 'pm_1055846_name_replace_data.txt'; my $out_file_name_replaced = 'pm_1055846_name_replaced_out.txt'; open my $in_id_fh, '<', $in_file_name_id; my %id_for = map { split } <$in_id_fh>; close $in_id_fh; my $re = '\b(' . join('|', keys %id_for) . ')\b'; open my $in_replace_fh, '<', $in_file_name_replace; open my $out_replaced_fh, '>', $out_file_name_replaced; while (<$in_replace_fh>) { s/$re/$id_for{$1}/g; print $out_replaced_fh $_; }