in reply to perl compile options
The runtime cost of a debugging-enabled perl varies depending on the sort of processing you're doing. Most of the time the cost is negligible, but in some cases it can be quite significant (eg if some debug variable is being malloced and released in a tight loop).
I'd suggest building a non-debugging perl and doing some comparative benchmarks on your own programs to see if the difference would be significant in your case.
Hugo
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