note tshori I was just trying to run cpan after trying to install the Bundle::CPAN module. The instructions on BioPerl, said to install the Bundle::CPAN module, leave cpan. Get in again and install Module::Build. I when I tried to get back again by typing cpan, it gave me that error. Thanks, for your response in any case, your point makes a lot of sense! <p></p> Cheers, T. 1016994 1017002