I can help with the ODBC setup, files etc (since I've written an ODBC driver and contributed to unixODBC) but I've never used the driver you are using. It looks like it needs something set up outside of normal ODBC (e.g. like an env var) but I cannot tell you what that is (e.g. with IBM's DB2 driver you have to DB2_INSTANCE env var or you get exactly the same error you are getting). Surely Microsoft have some docs to tell you what you need to do or perhaps the installer set something in your environment and you are logged in as someone else - just a guess. I'm surprised the installer did not create a driver section in your driver manager files for you.