in reply to Using 64 Bit Perl for Production Scripts.
Quite obviously, you need to research this answer, for your environment and the particular packages that you. intend to use. There’s simply no other way to find the reliable for-you answers that you need.
Generally speaking, I would suggest that in a native 64-bit environment, native 64-bit software should be used whenever possible. However, every scenario is at-least potentially different. You should therefore identify and enumerate the software packages that you need for this box, and check documentation for each of these. Every aspect of a production system must be verified in this manner. I would presume that a 64-bit setup is most likely to be the appropriate one for all hardware of recent vintage. However ... “Trust, but Verify.™”