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The biggest win about CGI::Application for me is that I can develop locally under good old slow CGI on my dev box, and know that it will run under mod_perl on the production server with no changes.
With mod_perl and Apache::DBI (connection cacheing) I can get application response times so good I didn't think they were possible. The server load is way down too.
If that were all, it would be enough, but you also get HTML::Template for free, and lots of handy prebuilt solution modules that might just do exactly what you want.
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