Q&A > database programming > What is the difference between ADO and ODBC ? - Answer contributed by Anonymous Monk
From experience in writing wrappers for both and profiling both using DevPartner I can actually say that ODBC is a lot faster. You trade of ease against performance when going with ADO. Though this depends on the wrapper you write and the way you use the ODBC calls.
Besides ODBC is portable between platforms and you can use it to read flat files, access files, excel files, sql server, oracle, mysql etc.