This is quite possibly a problem I noted before:

[Perl]# host ftp.cpan.ddns.develooper.com
ftp.cpan.ddns.develooper.com has address 149.20.20.135
ftp.cpan.ddns.develooper.com has address 168.143.19.69
[Perl]# host 149.20.20.135
135.20.20.149.in-addr.arpa is an alias for 135.128-27.20.20.149.in-add
+r.arpa.
135.128-27.20.20.149.in-addr.arpa domain name pointer mirrors1.kernel.
+org.
[Perl]#
[download]

Note the mirrors1.kernel.org. I found that they had (have?) an improperly configured FTP server. The problem is in the the last line of a multi-line reply, and a missing space:

Ref: CPANplus 5 minute timeout>

They were notified, but no response was ever received.

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