I voted for megatokyo
because that was the only choice I regularly read, though Piro seems more interested in marketing these days.
My all-time favorite webcomic was the now departed Exploitation Now
, whether it was focusing on porn stars and furry animals of questionable origins, or malcontent teenagers wishing to rule the world. My current fave is Patches
because, well, those rodents/bears/whatevers are so cute. Plus I think Kelly rocks as an artist. I also enjoy Okay Pants
, though the current Yeti theme isn't as fun as when Bello was around.
My favorite web drawings
are done by Sam Brown for his Exploding Dog
project, and Andrew Bell's Creatures in My Head