I voted for megatokyo because that was the only choice I regularly read, though Piro seems more interested in marketing these days.
in reply to My favorite web comic is:
My all-time favorite webcomic was the now departed Exploitation Now, whether it was focusing on porn stars and furry animals of questionable origins, or malcontent teenagers wishing to rule the world. My current fave is Patches because, well, those rodents/bears/whatevers are so cute. Plus I think Kelly rocks as an artist. I also enjoy Okay Pants, though the current Yeti theme isn't as fun as when Bello was around.
My favorite web drawings are done by Sam Brown for his Exploding Dog project, and Andrew Bell's Creatures in My Head.