My money is on Komodo, I use it all the time. Especially as it has debugging access built in and CVS access built in - it makes for a one stop shop for Perl programming.
I had used Eclipse with the EPIC plug-in previously. But on a big project with big files it got to be atrociously slow. I have used Eclipse again recently on a clients installation of the IBM Websphere environment and whilst the later versions are somewhat better it sure doesn't warrant a change back.
Komodo isn't free, but for the price with the Perl Developers Kit, it represents very good value.