Not really no. If possible, the best solution is to keep the program running all the time. (See for example, mod_perl)
is it sane to do that?
It's not going to be much faster (and quite possibly slower) than just compiling the modules at run-time. If you don't use all the modules all the time, you might get better results by using require and/or Autoloader to load code when you need it instead of all at once.