in reply to Help performing "random" access on very very large file
Where the information exceeds what can be stored in memory, the most usual solution is some kind of DBMS. Relational databases are only semi-infeasible for this kind of data structure in the sense you could store say 100000 lines in a BLOB and index those - an approach talked about but I have never seen tried.
The most common custom DBMS structure is indeed flat-file-based as has been mentioned.
But the most useful Perl implementations of non-relational database architecture are probably going to be the DBM family of modules. In particular, DBM::Deep (which has an underlying flat-file storage) looks perfect for your requirement.
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