Funny you should ask. I'm giving a talk about that at YAPC::NA and OSCON this summer. Both work well, and the reasons to choose one over the other can be subtle. I've had great experiences using mod_perl on large sites, but if you need super-cheap hosting or don't want to admin your own server, you should look at FastCGI.
in reply to Re^4: Perl 6 and Web Development
in thread Perl 6 and Web Development