If your variables have several hundred lines wide scopes, you've got a problem. Such a variable is just very very very slightly better than an outright global.
Keep in mind that Perl has BLOCK scoping, not subroutine scoping. So a variable declared within a block (whether it's a block that belongs to a loop, an if() or just a bare block) only "exists" within that block, not in the whole subroutine. So do declare your variables in the smallest possible block and you will not have to worry about accidentally "destroying" a variable. You can (and at times should) even create blocks just to restrict the scope of a variable!
Jenda
Enoch was right!
Enjoy the last years of Rome.