What bothers me the most is that in situations where someone is in the minority, they are already in a disadvantaged position to express a similar opinion. Most people don't like rocking the boat, they don't want to go against their peers, and they're slow to vocalize when they're uncomfortable, unhappy, or offended at something. Unless they get really angry, they're not likely to say anything.
We've already had a woman note that she was bothered by the comic. If that's the case, I expect that there are many more who felt the same and didn't speak up.
Respect. Common courtesy. Appropriate behavior. These aren't complicated concepts. We need to remember that what is acceptable in some situations may not be in others. Sexualized programming jokes are a good example of something not acceptable in this environment, IMO.