|Just another Perl shrine|
You'll likely find Visual Basic rather expressionless if compared to Perl, and you'll miss the covenient use of things like arrays of hashes of arrays, but I don't think the migration will be so hard as to learn one's first language. As other monks say, VisualBasic is actually good at GUIs and it makes quite convenient to automate Windows objects or to create automatable Windows objects. This means you can link it with Perl in many different ways - have a look at Win32::OLE, then you can use each tool for what it does best.
In general, I prefer Perl for my own stuff, but that's mostly very quickly written and text-oriented. If I have to write a piece of code I'll rapidly move to another Windows workstation, I'd write in in VB and let it polish and package for me.