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Additionally to the other posts here I've been using Tk and creating some great little apps. It finally adds a more professional looking application look to many of my scripts. Once I got use to the syntax it can be pretty quick to write a TK GUI. Using TK requires you to learn a new way of structuring your program because thinking in application windows structure is different to writing a standard script.
Additionally, once your GUI is written compiling it into a standalone EXE I've found can be very simple but can also become a complicated mish-mash depending on what you are attempting to do. The standard TK gui runs with an corresponding console. At times I've used console this as part of the application and left it there, at other times I didn't want it to appear. I've already tackled a lot of these types of problems in my own posts to perlmonks. I won't add links to all the nodes here but check out my user node. There is a lot of links to stuff in there. Feel free to email me directly if you have any questions.
UPDATE: This link http://theoryx5.uwinnipeg.ca/perltk/ was the first article I read on Tk, it was a great quick intro with lots of working examples. It will give you a good idea of the syntax behind Tk as well.
The Funkster of Mirth
Programming these days takes more than a lone avenger with a compiler. - sam
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