I am currently prototyping an application for a client in wxPerl. I will look at turning the prototype into an example for posting.
My understanding, and it is incomplete at best, is that where possible wxWidgets uses native controls and where it is not possible it implements a universal version of the control in question. If I understand your reasoning you are worried that this leads to wxWidgets only supporting a subset of features that are common to all platforms, thus missing out on more advanced features of individual platforms?
That sounds like a valid concern, but one I am unable to comment on with much insight. All I can say is I have yet to come across some feature I was unable to utilize due to limitations in wxWidgets. But for the most part my deployment target has been Windows, and perhaps I would have had a different experience deploying on OS X/*nix.
I have come across some issues with event handling being "different" across platforms, but they were fairly easily resolved.
For now, here are some links you might find useful regarding wxPerl in action:
Perhaps play with wxGlade and examine the generated code:
If you are on Windows and using ActiveState Perl then the following is a good resource as well:
There is no specific wxPerl documentation, but the wxWidgets documentation is enough and contains wxPerl specific notes:
Hopefully all of that is a good start for you, and I will look into posting a version of the prototype I am working on currently.