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Check out Parrot as of r24315 or newer. Configure and build it:
Build Perl 6:$ make -C languages/perl6/
Now build the new pbc_to_exe target. 'snifty:$ make pbc_to_exe
With the shiny new pbc_to_exe utility, make the perl6 binary:$ ./pbc_to_exe languages/perl6/perl6.pbc
Now you have a perl6 binary that can run Perl 6 programs:$ ./languages/perl6/perl6 languages/perl6/t/01-sanity/01-tap.t
Caveats: you need to build a shared libparrot with dynamic loading (the default Parrot build, I believe). Also, for now, you can only run the Perl 6 binary from the root directory of a Parrot checkout. Both problems are solveable. (I think the binary will work against an installed Parrot, though I'm not sure we install the supporting PBCs appropriately yet.)
Update: Updated to match recent changes.