How do I assign & substitute in one statement?

dfaure has asked for the wisdom of the Perl Monks concerning the following question: ⭐ (strings)

Is it possible to assign a value to a variable and then do a substitution on it in a single statement? For example suppose I want to start with a URL, remove a known host-domain name, then assign the remaining dir/filename to a variable. With two statements you could say:

$dirfilename = $url;
$dirfilename = s|http://foo.bar.com/||;
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