Corion is right - it doesn't run out of the box, since it needs image files of the fabrics. I have a tarball with the script and some sample swatches, so if anyone wants to play with it, /msg me and I'll pass that along.
Good suggestions for features, Corion - I see this project growing. It's been a great way for me to learn Perl. I'd eventually like to have a web interface for it, where you could click checkboxes on which fabrics you want in the quilt, and enter a weighting factor for each fabric.