I will also need to use AnyEvent in order to do asynchronous HTTP requests and IO file operations. The solution thus seems to be Wx + AnyEvent.
What is that?
Yeah, the "watching filehandles" thing is undated -- the 2.9 branch has added some support, though a lot of that depends on the OS -- you can always use Glib with wxWidgets :) Hey, even perl doesn't support it :)
I wouldn't like to start a project with a GUI Toolkit, and realize when the project gets bigger, that the GUI is too slow so i have to restart it from scratch.
Prototype -- simulate the type of performance you're expecting, its trivial (say, creating 10,000 buttons and 200-100-line-text-widgets)
But "HTTP requests and IO file operations" sounds wonderfully vague -- I don't think it'll matter what you choose
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