in reply to Bioinformatics: Slow Parsing of a Fasta File
I've never used any BioPerl modules myself (so I cannot say anything about their performance in general), but half an hour for reading ~200MB sounds extremely long indeed. That makes me wonder if the file is maybe not stored locally, i.e. you're doing I/O with some remote share...
Could you check if running something functionally similar, but without Bio::SeqIO — in its most simple case
while (<>) { print if /^>/; }
(or perl -ne "print if /^>/" Test.fasta as a one-liner) takes similarly long?
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