comparing columns using regular expression

[rocky13]

I have two files. File1 has three columns and file2 has one column. File2 is a subset(w/ some repetitions) of the second column from file1. Here is a subset of the data for each file:

file1:
Box of Joe     CA12DE    12345
Big Box        BA23DF    0123X
Small          FFFFF3    111XX
Big and Small  4F4FGG    XCA12
None           XXXXXX    00000

file2:
BA23DF
BA23DF
4F4FGG

I need to print the entire line from file1 that does NOT contain the rows in file2. The output should look like this:

Name          Number     Count
Box of Joe    CA12DE     12345
Small         FFFFF3     0123X
None          XXXXXX     00000

#!/usr/bin/perl

open(F1 "<file1.txt") or die "Can't open\n";
open(F2 "<file2.txt") or die "can't open\n";

my @field = ();
foreach (my $line = <F2>) {
    push (@field, $line);
}
my $string = join(",",@field);
my @f = split(/,/, $string);

my @unique_f = split(/,/, unique(@f));


while ($m_line = <F1>) {
if !($m_line =~ m/????????/i)





sub unique {
    my %seen = ();
    my @r = ();
    foreach my $a (@_) {
        unless ($seen{$a}) {
            push @r, $a;
            $seen{$a} = 1;
        }
    }
    return @r;
}


#I have gotten this far but now I want to use regular expression that 
+matches each entry of the second column of file1 to the entire @uniqu
+e_f.  Thus, if the match is NOT DEFINED, then it should print the who
+le line.
Thanks!