local vs. $self-> pointer to subroutine

ISAI student has asked for the wisdom of the Perl Monks concerning the following question:

Hello all. I can benchmark this, but I want to know if what I am doing makes sense. It pertains to the PERL 5.8.8 I have a module, and I have a foreach loop inside one of the modules which calls on sub isInst. So I run:

foreach my $var (@something) {
 $self->isInst($var)
}
[download]

However, it could be faster (it is in Python) to do the following:

my $func_Ref=\&$self->isInst;
foreach my $var (@something) {
 &$func_Ref($var)
}
[download]

Same may be done for other references, which need be accessed via the scalar $self. From knowing the internals of the PERL 5.8.8 engine, should there be any difference? Are there any known reccomendations? I could not find any.

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