I will also need to use AnyEvent in order to do asynchronous HTTP requests and IO file operations. The solution thus seems to be Wx + AnyEvent.

What is that?

Yeah, the "watching filehandles" thing is undated -- the 2.9 branch has added some support, though a lot of that depends on the OS -- you can always use Glib with wxWidgets :) Hey, even perl doesn't support it :)

I wouldn't like to start a project with a GUI Toolkit, and realize when the project gets bigger, that the GUI is too slow so i have to restart it from scratch.

Prototype -- simulate the type of performance you're expecting, its trivial (say, creating 10,000 buttons and 200-100-line-text-widgets)

But "HTTP requests and IO file operations" sounds wonderfully vague -- I don't think it'll matter what you choose

Prototyping, very good idea, thank you! :-)

I'm not sure where you heard that, or what sort of application they were talking about.

If you want a filehandle watcher in Gtk2, you can do that, Gtk2 is pretty good in my book, although I never had trouble with Tk's speed, unless the number of widgets were very large.

You can run mixed event loops by making one loop a master, and the other a slave. The slave loop gets pumped every so many milliseconds by a timer in the master loop. See Wx with Tk and here below is a Gtk2-Tk hybrid script. It may be useful.

#!/usr/bin/perl -w
use strict;
use Gtk2;
use Tk;

#setup Tk loop
my $mw = MainWindow->new(-title=>'Tk Window');
my $count_tk = 0;
my $labtk = $mw->Label(-textvariable =>\$count_tk)->pack; 

#setup Gtk2 loop
Gtk2->init;
my $count_gtk = 0;
my $window = Gtk2::Window->new('toplevel');
$window->set_title('Gtk2 Window');
my $glabel = Gtk2::Label->new("This is a  Gtk2 Label $count_gtk");
$window->add($glabel);
$window->show_all;

# make Tk loop the master, but you could make Gtk2 master if desired
# the lower the repeat rate, i.e. 1 ms, 
# will give more cpu time to the gtk2 loop
# this is sometimes called manually pumping the event loop
my $tktimer = $mw->repeat(10, sub{      
   $count_gtk++;
   $glabel->set_text("This is a  Gtk2 Label $count_gtk");
   Gtk2->main_iteration while Gtk2->events_pending;
   
   $count_tk++;
  });


$mw->Button(-text=>' Tk control Quit  ',
       -command => sub{exit}
        )->pack();

MainLoop;

########################################

[download]

If i understood well, AnyEvent is made so that one doesn't need to "plug" loops together manually, like you just showed me how to do (thank you!).
I think i'll go for an EV loop, with Gtk2 embedded (or Gtk3 if it works).

My question was very naive : it's the first time in years that i implement a GUI, and the first time that i use events too.
Thank you for reassuring me that Tk and Gtk2 are not slow. I don't remember where i read that Wx was faster, but these words can make newbies like me imagine that not-Wx is bound to be slow.