My last two jobs were at Perl/JS startups.
Perl is one of the best choices for a start-up because it's amazingly fast for for prototyping, it covers so much ground, and is such good glue.
During the years we worked on Viaweb I read a lot of job descriptions. A new competitor seemed to emerge out of the woodwork every month or so. [I would look] at their job listings. After a couple years of this I could tell which companies to worry about and which not to. The more of an IT flavor the job descriptions had, the less dangerous the company was. The safest kind were the ones that wanted Oracle experience. You never had to worry about those. You were also safe if they said they wanted C++ or Java developers. If they wanted Perl or Python programmers, that would be a bit frightening-- that's starting to sound like a company where the technical side, at least, is run by real hackers...
–Beating the Averages
(update: fixed bracket HTML.)