I tried, and couldn't find a way that would still allow me to place things in specific locations elsewhere in the window. When I tried this no matter what I tried, the sizers took over and put everything near the top of the window.
I may just have to rethink my design a bit.
Re^2: wxPerl Static Text alignment
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One way of keeping track (what goes where) is naming your sizer/container elements by position, and incorporating the parent/child relationship into the name. Afterwards you incorporate your action elements (text/buttons) and name then by purpose/property/action (email_input/email_text,submit_button,cancel_button... )