The main thing I am looking for is a way for a perl script to run like a metro-style/Windows Runtime (might have a newer name).
I can format a Tk window to look like a Metro/WinRT/? app (basically fullscreen and optimized layout for touch screens). By default, when the script executes Windows switches from the Start Screen to the Desktop, then the script is executed (With the desktop in the background).
Metro-style apps don't switch to the desktop when they execute, they run in an app container which is not tied to the traditional Windows desktop.
Windows 8 Application Development info on MSDN 