in reply to Perl under Win 2000 & IIS 5.0
You might want to check out Cannot run Perl under IIS or this.
Check to make sure you have E:\Perl (or whatever is appropriate for your isntallation) in your PATH environment variable.
Also, you need to have the same .pl extension defined at the OS level (file types within the folder options applet)
In Section
Seekers of Perl Wisdom