Simon Cozens gave a talk to the London Perl Mongers last week about Maypole which looks like a very powerful, simple way to develop Web/database applications
(see: Building Enterprise Web Applications with Maypole).
The Maypole Wiki compares various Perl application frameworks.
I also like the philosophy behind OpenFrame: abstract the features to provide an application framework that can work with a variety of protocols. I've found it hard to get my head round some of the ideas, and haven't got round to developing anything with it yet. If you don't need its flexibility, it might be overkill.
