This is a nit but anytime the symbol table is altered the method cache table is invalidated so all your calls to $obj->foo have to do the full @ISA check again as well. That makes it nice to do symbol table updates only as needed or preferrably before the cache is going to be desired.
Re: Re^3: (~OT) How to measure Perl skills?
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Sure. If you say $obj->foo more than once only the first time suffers an OO penalty. The rest are just hash lookups and IIRC aren't more expensive than function calls. The whole OO-penalty thing people go on about is really about the process of finding foo in $obj's @ISA but that only happens when there isn't a current cache entry to pull from.