My overall first impression is that Perl 6 will be much better than for Perl 5 for building really large systems, so I'd like to see some examples in E12 illustrating how Perl 6 scales better.
So far, I like it a lot. The only thing that has caused me to pull a face is the whitespace-changing semantics in the Methods section where Larry commented:
Yes, this is different from Perl 5. And yes, I know certain people hate it. They can write their own grammar.
This scares me enough to always put parens around function calls (which I mostly do in Perl 5 anyway). So, if you can unscare me, that would be nice. :-)