I don't think I fully understand the placeholder problem you're seeing. It may be Sybase-specific, and if you post the placeholder usage that didn't do what you wanted, you may get some better help.
But if it turns out you really do need to "fill out" the placeholder values by hand, here's how I've done it in the past:
my $sql = "insert into foo values (?,?,?)";
my @binds = qw/alpha beta gamma/;
my $i = 0;
$sql =~ s/\?/ $dbh->quote( $binds[$i++] ) /ge;
# "insert into foo values ('alpha','beta','gamma')"
Someone could probably golf this shorter, but you must
be careful not to replace question marks that appear in the bind values. For instance, I've seen code on CPAN
that would go wrong on this:
my $sql = "insert into foo values (?, ?)";
my @binds = ("Huh?", "What?");
# correct: "insert into foo values ('Huh?', 'What?')"
# mysqlPP: "insert into foo values ('Huh'What?'', ?)"
Got rid of \G business.