I have used both Event and POE for a variety of projects and am currently using Event for a very-high profile project which provides interaction between a real-time communication server and digital signage. The primary difference between these modules is that POE provides a more complete, abstract and higher level interface to the event queue - While this may permit more rapid development of event-based services, it does introduce additional code overhead to the event-based solution.
in reply to POE and time
As such, the choice between Event and POE is the same as any where selecting libraries that abstract core system services, balancing the ease of use and development offered by the abstracted interface against the performance cost levied by this abstraction - That being said, irrespective of the library selected, there is no reason why code could not be introduced to reference code performance against a known time source such as a NTP server.
perl -le "print unpack'N', pack'B32', '00000000000000000000001000000000'"