Edit - after vek slapped me :-)
Well, i prefer qx over backtics because it is more readable. my $result = `test.exe`; looks too similar to my $result = 'test.exe';. Using a qx instead signals that something special is happening here.
While I'm sure you have your reasons for preferring qx/STRING/ over `STRING`, perhaps it would help the OP if you'd expand on your reply a little and explain why. What benefits would the OP get from using one over the other?