My personal opinion is that in Perl I would need an extraordinary motivation to use multi-threading. Forking is almost always a better way to go on platforms that natively support it.
For a mass insertion into a database I would recommend neither approach. Instead I would suggest learning what native tools your database has for mass inserts. I would then use them. If the table you're inserting into has indexes I would strongly suggest dropping all indexes, doing the insert, then re-creating the indexes. (The reason for that is that maintaining indexes during inserts results in a lot of random seeks to disk. Seeking to disk is expensive. Throwing away the index and rebuilding it at the end avoids most of those seeks and is therefore much faster.)