in reply to
Is there an easy way to clean PERL in Fedora 10 and reinstall PERL
What do you mean by "I cannot invoke CPAN from the shell"? What unexpected behaviour do you see?
I don't recommend mixing RPM-installed modules with CPAN-installed modules in the same Perl installation. It's bound to lead to problems eventually (there's a chance it even led to whatever problems you're currently having).
The system Perl that comes with Fedora already has a number of RPM-installed modules with it. I therefore strongly recommend only installing new modules using RPM or yum. I know that not all CPAN modules are available that way but you have a couple of options. You can find new repositories that have other CPAN modules available (I run one such repository - and I take requests for new modules) or you can learn how to create your own RPMs from CPAN modules - it's really not that hard.
See my presentation Perl in RPM-Land for more details.