in reply to
OSX Separate Install: PerlBrew or Activestate?
Is it simply preference or are there any significant differences in how each perform, handle Perl installs and manage modules?
There is no difference in those respects.
ActiveState comes with the latest and greatest version of ppm and that is about it, the rest are modules on CPAN (like old version of ppm).
Also, if you buy a license, you also get some kind of support... ActiveState does patch some core modules, but nothing too radical.
Installing with cpan/cpanp/cpanm with either perl is the same, and like the documentation for perlbrew shows, you just modify your $PATH