README.macosx and perlport should tell you everything you need to know
Perl: perlintro perlretut perldoc Basic debugging checklist Yes, even you can use CPAN
PerlMonks: How do I post a question effectively? Markup in the Monastery How do I post a question effectively? I know what I mean. Why don't you?
General: How To Ask Questions The Smart Way What every computer scientist should know about floating-point arithmetic
To Be Continued...
In reply to Re: Are there any major Perl issues with Mac OS X Lion?