in reply to Cross-platform GUI for UNIX based scripts
If you AIM for perl based cross platform GUI, Go for GTK. You can develop GUI in GTK Glade GUI builder and only write call backs in perl (Kind of VB approach). I develop many perl based GUI in Perl GTK+, The great http://www.sisyphusion.tk/ repo has perl GTK PPMs for Windows too.
For code examples and screen shots have a look at http://code.google.com/p/saaral-soft-search-spider/
Thanks & Regards,
My Perl Gtk2 technology demo project - http://code.google.com/p/saaral-soft-search-spider/ , contributions are welcome.