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#!/usr/bin/perl
use warnings;
...
}

close $in_file;

## Sample of data file. Each file has hundreds of thousands of columns
+ and hundreds of rows
SAMPLE,16287215,16287226,16287365,16287649,16287784,16287851,16287912
...
HG00637,0 0,0 0,0 0,0 0,0 0,0 0,0 0
HG00638,0 0,0 0,0 0,0 0,0 0,1 1,0 0
HG00640,0 0,0 0,0 0,0 0,0 0,1 1,0 0