AFAIK it's possible to write linux kernel modules in Perl. It's probably a blessing for prototyping...
Another interesting thing I just discovered today : http://www.genezzo.com/. An "enterprise strength" RDBMS, with clustering and other high-end features, entirely written in Perl.
And then there's that CAD application prototype written in perl, Puzzle Bobble, and some others... Well, actually it seems anything can be done in Perl after all :)
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