I actually prefer to have all my text transliterated to Tengwar so serifs become a non-issue...

All joking aside though, it depends on the context and readability (can I tell the difference between 1/I/l/| and 0/O and ()/{}?) so serifs aren't a huge issue – it all comes down to readability. The most important question for me is whether the font is monospaced or proportional. I actually prefer monospaced fonts even when I'm not programming, because if I'm not coding it probably means that I'm writing with a proportional font that crams as much text in the smallest area possible (like Times New Roman) after 48 hours of straight work after drinking several pots of coffee at 3:00 AM the day my final research paper (in a subject that I don't even care about, no less) for the semester is due. As a fourth year University student, I often have nightmares which center around double spaced pages of 12 point Times New Roman.

In any case, I think most can agree that MS Comic Sans is an especially horrible font, and its eradication would be a blessing for humanity.