I'd agree that the context is important.
I prefer serif when reading blocks of text especially in hardcopy as the serif's do their job of helping the eye follow the line.
In other contexts a sans-serif just looks nicer.
When working at a hospital in the early 90's we did a survey for our documentation and most folk preferred 12pt sans-serif. Well until they had to read long documents when 10pt serif was more readable and used less paper.
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