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Here's an approach that avoids the scary  (?{ code }) and  (??{ code }) regex constructs, but whether it's more readable than your  while loop is another question.

>perl -wMstrict -le "my $s = '_+0GAA__+1GAA__+2GGAA__+3GGGAA_'; print qq{'$s'}; $s =~ s{ ( \+ (\d+) [ACGT]+ ) } { (my $r = $1) =~ s{ \+ \d+ [ACGT]{$2} }{}xms; $r }xmsge; print qq{'$s'}; " '_+0GAA__+1GAA__+2GGAA__+3GGGAA_' '_GAA__AA__AA__AA_'

Note that the  '+0ACGT' sequence is handled in a way that seems consistent with your original regex, but that I don't know to be correct.

Update: Here's a version using substr that might be a bit more readable.

>perl -wMstrict -le "my $s = '_+0GAA__+1GAA__+2GGAA__+3GGGAA_'; print qq{'$s'}; $s =~ s{ ( \+ (\d+) [ACGT]+ ) } { substr $1, 1 + length($2) + $2 }xmsge; print qq{'$s'}; " '_+0GAA__+1GAA__+2GGAA__+3GGGAA_' '_GAA__AA__AA__AA_'

In reply to Re: Regex fun by AnomalousMonk
in thread Regex fun by Hena

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