The short answer would be no.
From perlmacosx (specifically that last paragraph)
Support for 64-bit addressing is experimental: some aspects of Perl ma +y be omitted or buggy. Note the messages output by Configure for fur +ther information. Please use "perlbug" to submit a problem report in th +e event that you encounter difficulties. When building 64-bit modules, it is your responsiblity to ensure t +hat linked external libraries and frameworks provide 64-bit support: i +f they do not, module building may appear to succeed, but attempts to use + the module will result in run-time dynamic linking errors, and subsequ +ent test failures. You can use "file" to discover the architectures supported by a library: $ file libgdbm.3.0.0.dylib libgdbm.3.0.0.dylib: Mach-O fat file with 2 architectures libgdbm.3.0.0.dylib (for architecture ppc): Mach-O dynami +cally linked shared library ppc libgdbm.3.0.0.dylib (for architecture ppc64): Mach-O 64-bit + dynamically linked shared library ppc64 Note that this issue precludes the building of many Macintosh-spec +ific CPAN modules ("Mac::*"), as the required Apple frameworks do not p +rovide PPC64 support. Similarly, downloads from Fink or Darwinports are unlikely to provide 64-bit support; the libraries must be rebuilt +from source with the appropriate compiler and linker flags. For further information, see Apple's *64-Bit Transition Guide* at <http://developer.apple.com/documentation/Darwin/Conceptual/64bitP +orting /index.html>.
That last link no longer works and redirects you to a menu. Here's the updated page if you're interested: http://developer.apple.com/library/mac/#documentation/Darwin/Conceptual/64bitPorting/intro/intro.html