in reply to How do you load configuration variables
You don't need to re-boot, only re-start the process (See Re: Re: Updating Microsoft Windows (win32) environment variables for a fuller explanation).
However, that is probably equally inconvenient on a live system, so putting your configuration in a config file as sauoq suggested is probably better as well as more portable.
Whether making changes to a live system is a 'Good Thing' is another matter, but that's between you, your clients and your backup system:)
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