I was interested by the problem presented and wanted to play around with Inline C code in Strawberry Perl, so I came up with the code I have posted on AnomalousMonk's scratchpad
As one would expect from a C-coded solution, it is faster than the Pure Perl bitwise string differencing approach of GrandFather in Re: simple string comparison for efficiency: about 1000% for strings of 24,000 bases, about 350% for 240,000 bases (on my laptop: YMMV).
It uses an approach that, by happy accident, works for base characters A, C, T and G, and the don't-care character N. It can be extended a bit for other 'bases' (I know other characters are used to represent common base sequences), but sooner or later it will break down. There is a similar (and as yet untested) approach that I can think of that could reliably handle a much wider range of 'bases', but it would require a separate (but I think fairly fast), character-substitution encoding step to convert input files to a form amenable to differencing.
Please take a look at the material on my scratchpad and, if you think it is of interest, I can post it in this thread or in a new thread as you think best.
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