I've been wanting something like this for a long time. The last time I tooled around with Strawberry Perl I couldn't get many modules to install, looks like that situation has improved. I'll definitely give this a twirl.
I gave up on Gtk2 a long time ago - difficult to install, difficult to work with :( I went with Prima instead and have been very pleased.
With the reconfigure program CPAN installs modules that have no, or small amounts, C++ compiling required. That's not quite true, it installs those modules that only require the libraries that are already installed with the minGW distribution included in Strawberry Perl. So the comliling and linking could be extensive, but has to stay within these 'standard' libraries.
It also has problems with modules that have non-standard Makefile.PL scripts, especially ones that need extra command line arguments or hard coded file locations (eg. XML::Parser looks for eXpat in a version specific location on the C: drive, or requires flags passed to dmake). I also need to figure out if I need to incorporate the libraries from the Windows Platform SDK or Visual Studio (indications say yes).
Hmmm, for a while I've been wanting a mega-distribution of perl for windows, with all the popular libraries and whatnot bundled. I hate having to compile libraries over and over again.
Heh, perl used to be described as huge and bloated. But now the world has changed and Perl is one of the smaller serious languages. An all-in-one bundle would take up a bit of room, but it's a reasonable proposition - a Java install is 100+ Mb and I don't think perl runs to that.
I've got a bit of free time, I might see what I can come up with.
Installing Gtk2 etc. isn't a problem thanks to the nifty Glade/GTK+ project on SourceForge. No compiling needed there. It's specifically with compiling the Perl modules Gtk2 and Glib that provide Perl with interfaces with Gtk2.